منابع مشابه
A Tool to Utilize Adverse Effect Profiles to Identify Brain-Active Medications for Repurposing
BACKGROUND To shorten the time required to bring new treatments to clinics, recent efforts have focused on repurposing existing Food and Drug Administration (FDA)-approved drugs with established safety data for new indications. We hypothesized that adverse effect profiles might aid in prioritizing compounds for investigation in central nervous system (CNS) applications by providing an indicatio...
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This paper presents an ontology-based framework for repurposing learning object components. Unlike the usual practice where learning object components are assembled manually, the proposed framework enables on-the-fly access and repurposing of learning object components. The framework supports two processes: the decomposition of learning objects into their components as well as the automatic ass...
متن کاملThe purpose of repurposing
The goal of developing drugs that act at a single target – the long-standing focus on discovering the 'magic bullet' – as enticing and enduring as it has been, has not proven to be a uniformly successful endeavor. Most complex disorders, including those not only in oncology but also in neurology and neuropsychiatry, whether in their initial stages or in their progression, are not mediated by a ...
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compound dimethyl fumarate (DMF) has been an approved drug in Europe for several decades as a therapeutic for psoriasis and relapsing-remitting multiple sclerosis (MS). More recently, the drug has been approved in The United States as an MS treatment (Tecfidera®). Upon ingestion, the drug is rapidly metabolized into the biologically active form of the agent, mono methyl fumarate (MMF); the biol...
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Taking medications during breastfeeding is common and physicians are usually asked about the safety of prescribed medicines, herbal medications, or tobacco and alcohol consumption during lactation. Safety of medications during breastfeeding is related to maternal factors, neonatal factors and the type of medication, In the case of necessity of taking medication for the mother, there are ways to...
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ژورنال
عنوان ژورنال: The Ocular Surface
سال: 2021
ISSN: 1542-0124
DOI: 10.1016/j.jtos.2020.11.012